Protein Design & Engineering
From sequence to structure to function, we design for efficacy and developability.
Mosaic designs, engineers, and optimizes therapeutic proteins from early concept through candidate selection.
By combining computational design, diverse expression systems, and rigorous analytics, we deliver molecules that balance biological activity with manufacturability. Library-based protein engineering using yeast display is a core component of our platform, enabling affinity maturation, specificity refinement, and liability reduction through iterative, data-driven optimization.
Engineering decisions made early influence manufacturability, stability, and translational performance. Our workflows are designed to surface risk early and support confident progression.
Engineered protein variants are frequently evaluated using cell-based assays to confirm biological activity and downstream signaling.
Protein Engineering Services
Design & Humanization
Computational modeling and humanization strategies that preserve function while improving developability and reducing immunogenicity risk.
Library-Based Protein Engineering (Yeast Display)
Library-based yeast display enables de novo discovery and iterative optimization of antibody and protein leads, supporting affinity maturation, specificity refinement, and reduction of developability liabilities.
Multispecifics & Bispecifics
Modular architectures, including common light chain approaches, supported by library-based engineering and yeast display, to build multispecific molecules with monoclonal-like manufacturability.
Expression & Purification
Platform-agnostic expression across bacterial, yeast, insect, and mammalian systems. Custom purification, refolding, and low-endotoxin preparation for in vivo use.
Bioconjugation & Glycoengineering
Site-specific modifications and tailored glycosylation strategies to tune PK/PD, targeting, and therapeutic index.
Developability & Optimization
Iterative engineering cycles—including library-based optimization via yeast display—to improve affinity, stability, solubility, and immunogenicity risk, supported by comprehensive biophysical characterization and early developability screening.
Protein Modalities We Engineer
Antibodies
Cytokines
Proteases
Soluble receptors
Engineered scaffolds
Typical Timelines
At Mosaic, we combine scientific expertise, strategic planning, and collaborative execution to advance therapeutic programs efficiently and effectively.
Explore Mosaic’s broader biologics discovery solutions supporting protein engineering, antibody discovery, and functional evaluation.
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Start a conversation with our scientific team about your biologic discovery program.
Explore Other Discovery Solutions
Complementary capabilities supporting biologics discovery, engineering, and characterization.
Antibody Discovery & Optimization
Cell Based Assays
Protein Sciences & Analytics
